منابع مشابه
Dmd053322 2018..2023
In vitro–in vivo correlation (IVIVC) of intrinsic clearance in preclinical species of rat and dog was established using the hepatocyte relay method to support high-confidence prediction of human pharmacokinetics for low-clearance compounds. Good IVIVC of intrinsic clearance was observed for most of the compounds, with predicted values within 2-fold of the observed values. The exceptions involve...
متن کاملDmd059675 2023..2032
Cerlapirdine (SAM-531, PF-05212365) is a selective, potent, full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor. Cerlapirdine and other 5-HT6 receptor antagonists have been in clinical development for the symptomatic treatment of Alzheimer’s disease. A human absorption, distribution, metabolism, and excretion study was conducted to gain further understanding of the metabolism and disp...
متن کاملDev104240 2014..2023
Tissue homeostasis is maintained by adult stem cells, which selfrenewand give rise to differentiating cells. The generation of daughter cells with different fates is mediated by signalling molecules coming from an external niche or being asymmetrically dispatched between the two daughters upon stem cell mitosis. In the adult Drosophila midgut, the intestinal stem cell (ISC) divides to generate ...
متن کاملResearch Programme for 2018–2023
Its statutes give the IEG the task of conducting research into the traditions, transformations and crises especially of religious, political and social differentiations, their effects, and the possibilities for overcoming them. This mandate was fulfilled with the central theme of the research programme from 2012 to 2017, »negotiating differences in Europe«, by applying it to an interdepartmenta...
متن کاملLimnol. Oceanogr., 44(8), 1999, 2017–2023
High-latitude rivers supply the Arctic Ocean with a disproportionately large share of global riverine discharge and terrigenous dissolved organic matter (DOM). We used the abundance of lignin, a macromolecule unique to vascular plants, and stable carbon isotope ratios (d13C) to trace the high molecular weight fraction of terrigenous DOM in major water masses of the Arctic Ocean. Lignin oxidatio...
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ژورنال
عنوان ژورنال: Journal of Dairy Science
سال: 2023
ISSN: ['0022-0302', '1525-3198', '1529-9066']
DOI: https://doi.org/10.1016/s0022-0302(23)00017-6